[Mristudio-users] measureing Volume of CST

[susumu mori]

Hi Venkateswaran,

There are several ways;

1) Manual delineation: CST goes through the corona radiata, internal
capsule, cerebral peduncle, pons, and medulla. As it descends, the size
seems to reduce but this is because there are so many fibers running
parallel; some go to the thalamus, midbrain, pons, and cerebellum. So, it
would be difficult to manually define the pure CST at the higher slices at
the level of the corona radiata, internal capsule, and cerebral peduncle.
You can manually define it at the pons where you can find much purer CST.
For the manual delineation, you can use DtiStudio but I suggest RoiEditor
which has better interface for ROI drawing.
2) Tractography: You can use multiple ROIs to extract a trajectory that
mimics the known CST trajectory. Once you reconstruct it, you can count the
number of the pixels occupied by the reconstructed CST. You can use "Fiber
Tracking" function in DtiStudio and the "Statistics" button to get the
number of pixels. This may sound better method, but you may find a large
amount of variability among individuals.

Susumu

On Tue, Jul 14, 2009 at 10:23 AM, Rajagopalan, Venkateswaran <
rajagov2 at ccf.org> wrote:

>  Dear MRI studio Users,
>
> I am wondering is there a way to measure quantitatively the volume of CST.
> If so can anyone please tell me how to do it  using DTI studio. In essence
> we are interested in seeing whether CST tract volume is reduced in our ALS
> patients when compared to controls.
>
> Thanks
>
> Regards
> venkateswaran
>
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