[Mristudio-users] measureing Volume of CST

[Rajagopalan, Venkateswaran]

Dear Dr.Mori,
 
Thank you very much for your kind information. I will adopt your second approach as we need to measure FA and other DTI metrics also along the CST. 
 
Thanks again for your kind help.
 
Regards
venkateswaran

________________________________

From: mristudio-users-bounces at mristudio.org on behalf of susumu mori
Sent: Sat 7/18/2009 9:01 AM
To: DTI Studio, ROI Editor, Landmarker Questions/Support
Subject: Re: [Mristudio-users] measureing Volume of CST


Hi Venkateswaran,

There are several ways;

1) Manual delineation: CST goes through the corona radiata, internal capsule, cerebral peduncle, pons, and medulla. As it descends, the size seems to reduce but this is because there are so many fibers running parallel; some go to the thalamus, midbrain, pons, and cerebellum. So, it would be difficult to manually define the pure CST at the higher slices at the level of the corona radiata, internal capsule, and cerebral peduncle. You can manually define it at the pons where you can find much purer CST. For the manual delineation, you can use DtiStudio but I suggest RoiEditor which has better interface for ROI drawing.
2) Tractography: You can use multiple ROIs to extract a trajectory that mimics the known CST trajectory. Once you reconstruct it, you can count the number of the pixels occupied by the reconstructed CST. You can use "Fiber Tracking" function in DtiStudio and the "Statistics" button to get the number of pixels. This may sound better method, but you may find a large amount of variability among individuals.

Susumu


On Tue, Jul 14, 2009 at 10:23 AM, Rajagopalan, Venkateswaran <rajagov2 at ccf.org> wrote:


	Dear MRI studio Users,
	 
	I am wondering is there a way to measure quantitatively the volume of CST. If so can anyone please tell me how to do it  using DTI studio. In essence we are interested in seeing whether CST tract volume is reduced in our ALS patients when compared to controls. 
	 
	Thanks
	 
	Regards
	venkateswaran

	

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