Hi <font size="2" face="Arial">Venkateswaran,<br><br>There are several ways;<br><br>1) Manual delineation: CST goes through the corona radiata, internal capsule, cerebral peduncle, pons, and medulla. As it descends, the size seems to reduce but this is because there are so many fibers running parallel; some go to the thalamus, midbrain, pons, and cerebellum. So, it would be difficult to manually define the pure CST at the higher slices at the level of the corona radiata, internal capsule, and cerebral peduncle. You can manually define it at the pons where you can find much purer CST. For the manual delineation, you can use DtiStudio but I suggest RoiEditor which has better interface for ROI drawing.<br>
2) Tractography: You can use multiple ROIs to extract a trajectory that mimics the known CST trajectory. Once you reconstruct it, you can count the number of the pixels occupied by the reconstructed CST. You can use "Fiber Tracking" function in DtiStudio and the "Statistics" button to get the number of pixels. This may sound better method, but you may find a large amount of variability among individuals.<br>
<br>Susumu<br></font><br><div class="gmail_quote">On Tue, Jul 14, 2009 at 10:23 AM, Rajagopalan, Venkateswaran <span dir="ltr"><<a href="mailto:rajagov2@ccf.org">rajagov2@ccf.org</a>></span> wrote:<br><blockquote class="gmail_quote" style="border-left: 1px solid rgb(204, 204, 204); margin: 0pt 0pt 0pt 0.8ex; padding-left: 1ex;">
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<div><font size="2" color="#000000" face="Arial">Dear MRI studio Users,</font></div>
<div><font size="2" face="Arial"></font> </div>
<div><font size="2" face="Arial">I am wondering is there a way to measure quantitatively the volume of CST. If so can anyone please tell me how to do it using DTI studio. In essence we are interested in seeing whether CST tract volume is reduced in our ALS patients when compared to controls. </font></div>
<div><font size="2" face="Arial"></font> </div>
<div><font size="2" face="Arial">Thanks</font></div>
<div><font size="2" face="Arial"></font> </div>
<div><font size="2" face="Arial">Regards</font></div>
<div><font size="2" face="Arial">venkateswaran</font></div>
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