[Mristudio-users] Studies on animal histology after performing brain resection?

[Dorian Pustina]

Thank you Dr. Mori,

Studies with DTI are several, the problem is that diffusion does not give
clear indications of biological processes like remyelination or
hyper-plasticity, all being complicated by the problem of crossing fibers.
Histology would be needed for this, but there don't seem to be much on this
side.

Thank you for responding.

Dorian


2014-05-30 10:06 GMT-04:00 Susumu Mori <smoriw at gmail.com>:

> Hi Dorian,
>
> The lesion-based analysis is an old-school method and I'm not aware of new
> systematic studies recently. Consequently, I imagine that it is difficult
> to find papers with modern imaging methods.
>
> For human study, I remember Chris Beaulieu in Alberta published
> longitudinal DTI studies after stroke in human.
> Jiangyang Zhang's group published some paper after hypoxic injuries. I
> guess most of the system perturbation is caused by genetic or some kind of
> treatment these days, rather than resection.
>
>
>
> On Tue, May 27, 2014 at 9:33 AM, Dorian Pustina <albnet at gmail.com> wrote:
>
>> Dear all,
>>
>> I am trying to find some animal studies of biological changes in the
>> brain (i.e. axonal sprouting or myelination) after performing resection. I
>> searched for a while the literature but there is not much I could find.
>> There are either studies on spinal cord, or histology of areas proximal to
>> the resection, but not what happens in areas more distal from the resection
>> (i.e. if there is sprouting or change in myelination/oligodendrocytes).
>>
>> The original Song 2002 paper that related radial diffusivity with
>> myelination is on shiverer mouse, and all ~300 papers  that cite him/her
>> don't seem to have done histology comparisons in resected brains.
>>
>> Having some animal models to compare diffusion changes observed in humans
>> would be great. Does anybody remember any such study that looked at
>> histology in animals after performing controlled resection (possibly not
>> just chemical lesions)?
>>
>> Thank you for any help.
>> Dorian
>> TJU
>>
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