[Mristudio-users] Studies on animal histology after performing brain resection?

[Susumu Mori]

Hi Dorian,

The lesion-based analysis is an old-school method and I'm not aware of new
systematic studies recently. Consequently, I imagine that it is difficult
to find papers with modern imaging methods.

For human study, I remember Chris Beaulieu in Alberta published
longitudinal DTI studies after stroke in human.
Jiangyang Zhang's group published some paper after hypoxic injuries. I
guess most of the system perturbation is caused by genetic or some kind of
treatment these days, rather than resection.



On Tue, May 27, 2014 at 9:33 AM, Dorian Pustina <albnet at gmail.com> wrote:

> Dear all,
>
> I am trying to find some animal studies of biological changes in the brain
> (i.e. axonal sprouting or myelination) after performing resection. I
> searched for a while the literature but there is not much I could find.
> There are either studies on spinal cord, or histology of areas proximal to
> the resection, but not what happens in areas more distal from the resection
> (i.e. if there is sprouting or change in myelination/oligodendrocytes).
>
> The original Song 2002 paper that related radial diffusivity with
> myelination is on shiverer mouse, and all ~300 papers  that cite him/her
> don't seem to have done histology comparisons in resected brains.
>
> Having some animal models to compare diffusion changes observed in humans
> would be great. Does anybody remember any such study that looked at
> histology in animals after performing controlled resection (possibly not
> just chemical lesions)?
>
> Thank you for any help.
> Dorian
> TJU
>
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