[Mristudio-users] DTI & clinical featues of Lewy Body Spectrum Disease Grant

[susanne steinberg]

Hello Again

I thought I would include the start I made on the DTI protocol. 

We will acquire a two diffusion sequences (80 axial slices, voxel size 2 mm
isotropic, TR/TE=11000/75 ms, 64 gradient directions, b = 1000 s/mm2 and b =
3000 s/mm2).  

Diffusion Imaging Data Analysis: Diffusion models will be fitted to the data
using standard approached in the field (FSL motion correction, noise
filtering and model reconstruction). Fractional anisotropy and diffusivity
maps will be computed for each of the subjects after registration to the Eve
DTI template. Group-wise voxel-based analysis will identify regions
implicated in the disorder. In addition, the integrity of the tracts such as
anterior, inferior and posterior limbs of the internal capsule, inferior
fronto-occipital fasciculus, superior longitudinal fasciculus (prefrontal
area), inferior longitudinal fasciculus (precuneus), cingulum bundle and
corpus callossum (splenium, genu), posterior thalamic radiation, anterior,
superior & posterior corona radiata and the fornix will be investigated
using fiber tracking and measures of anisotropy and diffusivity computed
along these tracts. 

Please assist. Thank-you Susanne

 

From: susanne steinberg [mailto:susanne.steinberg45 at gmail.com] 
Sent: Tuesday, November 05, 2013 8:01 AM
To: 'DTI Studio, ROI Editor, DiffeoMap Questions/Support'
Cc: 'Steinberg, Susanne'
Subject: DTI & clinical featues of Lewy Body Spectrum Disease Grant
Importance: High

 

Dear Dr. Mori and Experts

I am applying for two pilot grants on the subject of the association of
white matter integrity, neuropsychiatric symptoms and  mild neurocognitive
impairment in Lewy Body Dementia and Parkinson's Disease. There has been
much debate whether these diseases are separate entities or whether they are
the actually one disease with variable clinical presentation. This has
prevented us from finding the best biomarker for early diagnosis and
treatment.  I have reviewed the literature on DTI in Lewy Body Spectrum
Diseases, there are some interesting results but there is much more to learn
to answer my research question.

I need help to set up the DTI protocol which could be run at UPenn. I have
been to the MRIStudio but have had no reason to use what I learnt but now I
do. I am also interested in adding a protocol for high angular resolution
imaging. Have you been using that at all? We have wonderful neuroimaging
experts on Aging but not in DTI or HARDI. I think the answers lie in
multimodal approach to imaging (ASL, volumetric MRI and DTI/HARDI)

 

Thanks for considering this request.

Susanne 

 

Susanne Inez Steinberg MD, MBA, MSCE
Director of Geriatric Psychiatrist & Senior Research Associate
Crozer Chester Medical Center & Children's Hospital Of Pennsylvania
One Medical Center Blvd
Philadelphia, PA 19013
Crozer Telephone: 610-874-5257

CHOP Telephone: 267-426-6047

Cell: 215-287-2961
Email:  <mailto:susanne.steinberg at crozer.org> susanne.steinberg at crozer.org

Emai:l  <mailto:susanne.steinberg45 at gmail.com> susanne.steinberg45 at gmail.com

Email:  <mailto:steinbergs1 at email.chop.edu> steinbergs1 at email.chop.edu

 

 






 

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