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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'>Hello Again<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'>I thought I would include the start I made on the DTI protocol. <o:p></o:p></span></p><p class=MsoListParagraph style='margin:0in;margin-bottom:.0001pt;line-height:normal'><span style='font-size:12.0pt;font-family:"Arial","sans-serif"'>We will acquire a two diffusion sequences (80 axial slices, voxel size 2 mm isotropic, TR/TE=11000/75 ms, 64 gradient directions, b = 1000 s/mm<sup>2 </sup>and b = 3000 s/mm<sup>2</sup>). <b><o:p></o:p></b></span></p><p class=MsoListParagraph style='mso-margin-top-alt:6.0pt;margin-right:0in;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal'><b><span style='font-size:12.0pt;font-family:"Arial","sans-serif"'>Diffusion Imaging Data Analysis: </span></b><span style='font-size:12.0pt;font-family:"Arial","sans-serif"'>Diffusion models will be fitted to the data using standard approached in the field (FSL motion correction, noise filtering and model reconstruction). Fractional anisotropy and diffusivity maps will be computed for each of the subjects after registration to the Eve DTI template. Group-wise voxel-based analysis will identify regions implicated in the disorder. In addition, the integrity of the tracts such as anterior, inferior and posterior limbs of the internal capsule, inferior fronto-occipital fasciculus, superior longitudinal fasciculus (prefrontal area), inferior longitudinal fasciculus (precuneus), cingulum bundle and corpus callossum (splenium, genu), posterior thalamic radiation, anterior, superior & posterior corona radiata and the fornix will be investigated using fiber tracking and measures of anisotropy and diffusivity computed along these tracts. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'>Please assist. Thank-you Susanne<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> susanne steinberg [mailto:susanne.steinberg45@gmail.com] <br><b>Sent:</b> Tuesday, November 05, 2013 8:01 AM<br><b>To:</b> 'DTI Studio, ROI Editor, DiffeoMap Questions/Support'<br><b>Cc:</b> 'Steinberg, Susanne'<br><b>Subject:</b> DTI & clinical featues of Lewy Body Spectrum Disease Grant<br><b>Importance:</b> High<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Dear Dr. Mori and Experts<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>I am applying for two pilot grants on the subject of the association of white matter integrity, neuropsychiatric symptoms and mild neurocognitive impairment in Lewy Body Dementia and Parkinson’s Disease. There has been much debate whether these diseases are separate entities or whether they are the actually one disease with variable clinical presentation. This has prevented us from finding the best biomarker for early diagnosis and treatment. I have reviewed the literature on DTI in Lewy Body Spectrum Diseases, there are some interesting results but there is much more to learn to answer my research question.<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>I need help to set up the DTI protocol which could be run at UPenn. I have been to the MRIStudio but have had no reason to use what I learnt but now I do. I am also interested in adding a protocol for high angular resolution imaging. Have you been using that at all? We have wonderful neuroimaging experts on Aging but not in DTI or HARDI. I think the answers lie in multimodal approach to imaging (ASL, volumetric MRI and DTI/HARDI)<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Thanks for considering this request.<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Susanne <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal>Susanne Inez Steinberg MD, MBA, MSCE<br>Director of Geriatric Psychiatrist & Senior Research Associate<br>Crozer Chester Medical Center & Children's Hospital Of Pennsylvania<br>One Medical Center Blvd<br>Philadelphia, PA 19013<br>Crozer Telephone: 610-874-5257<o:p></o:p></p><p class=MsoNormal>CHOP Telephone: 267-426-6047<o:p></o:p></p><p class=MsoNormal>Cell: 215-287-2961<br>Email: <a href="mailto:susanne.steinberg@crozer.org"><span style='color:windowtext'>susanne.steinberg@crozer.org</span></a><o:p></o:p></p><p class=MsoNormal>Emai:l <a href="mailto:susanne.steinberg45@gmail.com"><span style='color:windowtext'>susanne.steinberg45@gmail.com</span></a><o:p></o:p></p><p class=MsoNormal>Email: <a href="mailto:steinbergs1@email.chop.edu"><span style='color:windowtext'>steinbergs1@email.chop.edu</span></a><o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#888888'><br></span><br><br><o:p></o:p></p></div><p class=MsoNormal><o:p> </o:p></p></div></div></body></html>