[Mristudio-users] Pediatric atlas question

[susumu mori]

Hi Ashley,

I think there is no easy answer to your question. A required precision of a
tool is always a function of the effect size you are going after.

Our experience tells that once subjects reach 3-4 years, anatomical
differences between pediatric  and adult brains are not much more than
individual variability within adult populations and thus registration
accuracy by using an adult atlas for the pediatric population would be
similar to adult populations.

However, we can always argue that age-dependent atlas would provide more
accurate registration and detect more subtle differences.

Below 24 months, especially below 12 months, the brain anatomy is
significantly different from adults and you need age-matched atlases for
accurate registration.

Susumu

On Fri, Aug 3, 2012 at 9:47 PM, Ashley Saito <ashley.saito at gmail.com> wrote:

> Hello,
>
> My name is Ashley and I am a medical student working with Dr. Chang to
> analyze some of her pediatric DTI data. We have subjects between 3-9 years
> of age, and were wondering which atlas you would recommend using. Should we
> use the 24month pediatric atlas off of http://cmrm.med.jhmi.edu/ or the
> standard talairach single subject atlas? Alternatively, could we use age
> specific single subjects off of http://cmrm.med.jhmi.edu/ new pediatric
> dti data set page? Your input would be greatly appreciated.
>
> Thank you!
> Ashley
>
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