Hi Ashley,<div><br></div><div>I think there is no easy answer to your question. A required precision of a tool is always a function of the effect size you are going after. </div><div><br></div><div>Our experience tells that once subjects reach 3-4 years, anatomical differences between pediatric and adult brains are not much more than individual variability within adult populations and thus registration accuracy by using an adult atlas for the pediatric population would be similar to adult populations.</div>
<div><br></div><div>However, we can always argue that age-dependent atlas would provide more accurate registration and detect more subtle differences.</div><div><br></div><div>Below 24 months, especially below 12 months, the brain anatomy is significantly different from adults and you need age-matched atlases for accurate registration.</div>
<div><br></div><div>Susumu<br><br><div class="gmail_quote">On Fri, Aug 3, 2012 at 9:47 PM, Ashley Saito <span dir="ltr"><<a href="mailto:ashley.saito@gmail.com" target="_blank">ashley.saito@gmail.com</a>></span> wrote:<br>
<blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Hello,<br><br>My name is Ashley and I am a medical student working with Dr. Chang to analyze some of her pediatric DTI data. We have subjects between 3-9 years of age, and were wondering which atlas you would recommend using. Should we use the 24month pediatric atlas off of <a href="http://cmrm.med.jhmi.edu/" target="_blank">http://cmrm.med.jhmi.edu/</a> or the standard talairach single subject atlas? Alternatively, could we use age specific single subjects off of <a href="http://cmrm.med.jhmi.edu/" target="_blank">http://cmrm.med.jhmi.edu/</a> new pediatric dti data set page? Your input would be greatly appreciated.<br>
<br>Thank you!<span class="HOEnZb"><font color="#888888"><br>Ashley<br>
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