[Mristudio-users] Fiber-based transformation?

[susumu mori]

Do you mean, you want to align fiber-to-fiber between two brains?
If that is the question, no, we don't, but you can do the following.

For example, you can do tractography of the corticospinal tract (CST) in
two brains. Convert the tract information to a binary masking image, in
which pixels that contain the tract are "1" and the rests are "0".

>From the two brains, you can obtain two CST 1/0 binary images.

You can submit these two images by DiffeoMap for image matching. What will
happen then is, these two maps will be perfectly registered. Then you can
apply the transformation matrix to real images such as FA, b0, or
co-registered T1. However, I think this will register only the pixels that
belong to the CST and the rest of the brain is not well registered.

You can keep creating tracts like 10 more tracts. Then you will have 10 x 2
binary images from the two brains. You can submit 10-channel LDDMM throuth
DiffeoMap or you can combine the 10 binary images by assigning different
numbers; the CST is "1", SLF is "2", corpus callosum is "3", etc. Then you
can do 1-channel LDDMM. You can add FA map and do 2-channel LDDMM.

I thought of this kind of approach before but because the results of
tractography is quite noisy, I'm not sure if it improves the registration
accuracy....

On Tue, Apr 17, 2012 at 9:57 AM, <baiye at mail.ustc.edu.cn> wrote:

> Hi!
>
> Thank you for your time. I have some questions regarding DTI
> transformation.
>
> Does DTI Studio or DiffeoMap provide a transformation option that is not
> voxel-based but fiber-based?
>
> Or is there a human white matter fiber template that can be used to
> register with?
>
> Thank you again!
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