Cross-contract registration is difficult.<div>Theoretically, you can't expect accurate registration because different contrast reveal different structures in different ways. If you use non-linear registration like LDDMM, even with mutual information, you may not get anatomically correct registration.</div>
<div><br></div><div>If you use linear registration, most of the information comes from the brain boundary. Therefore, if you have T1 and T2 from the same subject, you can expect fairly accurate registration using rigid registration.</div>
<div><br></div><div>So, cross-contrast linear may work, but cross-contrast non-linear is difficult.</div><div><br></div><div>DTI is more complicated because it has B0 susceptibility non-linear distortion. Therefore T1-DTI requires non-linear registration, which leads to cross-contrast non-linear registration, which is inaccurate. </div>
<div><br></div><div>One thing you can try is to register DTI-b0 and anatomical-T2, which are both T2 contrasts. Between these two, you can do non-linear registration. This is how we reduce B0 distortion. Then you can register T1-T2 anatomical scans by linear registration.</div>
<div><br></div><div>This is the only way I can think of. Namely use the anatomical T2 as a hub to do intra-subject multi-contrast registration.<br><br><div class="gmail_quote">On Tue, Mar 12, 2013 at 3:51 PM, Dorian P. <span dir="ltr"><<a href="mailto:alb.net@gmail.com" target="_blank">alb.net@gmail.com</a>></span> wrote:<br>
<blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Hi all,<div><br></div><div>What it the best way to register DTI data onto T1? Or, if this is difficult, the way round, register T1 on DTI.</div>
<div><br></div><div>I have tried several ways in DTIstudio and Diffeomap without success.</div>
<div><br></div><div>Thank you.</div><span class="HOEnZb"><font color="#888888"><div><br></div><div>Dorian</div>
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