Cross-contrast image registration is always difficult. This applies for regular intra-data DTI image registration in which DWIs are registered to b0. If you have aDWI, the contrasts between two images will be much closer and co-registration may work better, but in theory, you can not correct the eddy current for which b0 is used as the non-distorted reference, although modern scanners should not have much eddy current distortion anymore. <br>
<br>Another issue you need to worry is that aDWI may contain motion-caused mis-registration in it. Then aDWI may not be a good reference.<br><br>If you haven't read DtiStudioUpdate.doc in <a href="https://www.mristudio.org/wiki/changelog/dtistudio-3.0.2">https://www.mristudio.org/wiki/changelog/dtistudio-3.0.2</a>, please study it, although it doesn't completely answer your question.<br>
<br><div class="gmail_quote">On Mon, Apr 26, 2010 at 10:37 PM, [Seongjin] <span dir="ltr"><<a href="mailto:choisj70@gmail.com">choisj70@gmail.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="border-left: 1px solid rgb(204, 204, 204); margin: 0pt 0pt 0pt 0.8ex; padding-left: 1ex;">
Using a fixed noise level, I tried two reference images for AIR.<div>This was done only for intra-individual registration not for spatial normalization.</div><div>Because I did not want to wash out individual difference.<br>
<div><br></div><div>1. b=0 image</div><div><br></div><div>2. aDWI (generated using DTI studio, average of all raw DWIs)</div><div><br></div><div>Test results for some data sets, AIR results from 2 visually appeared to be better, i.e. less motion.</div>
<div><br></div><div>Is there any better suggestion for reference image for AIR in DTI studio?</div><div><br></div><div>-SC</div></div>
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