[Mristudio-users] DTI on T1 registration

[Dorian P.]

Sounds good, but we don't acquire T2.

I tried playing around with FA, but didn't work initially. Perhaps
segmenting the T1 into grey and white matter and using only the white
matter to coregister with FA may work somehow. that should work with AIR
non linear as well, would be curious is someone ever tried it.

About rigid only, the proportions of the brain are different between DTI
and T1, so without some affine it really can't do much.

Thamk you.

Dorian



2013/3/12 susumu mori <susumu at mri.jhu.edu>

> Cross-contract registration is difficult.
> Theoretically, you can't expect accurate registration because different
> contrast reveal different structures in different ways. If you use
> non-linear registration like LDDMM, even with mutual information, you may
> not get anatomically correct registration.
>
> If you use linear registration, most of the information comes from the
> brain boundary. Therefore, if you have T1 and T2 from the same subject, you
> can expect fairly accurate registration using rigid registration.
>
> So, cross-contrast linear may work, but cross-contrast non-linear is
> difficult.
>
> DTI is more complicated because it has B0 susceptibility non-linear
> distortion. Therefore T1-DTI requires non-linear registration, which leads
> to cross-contrast non-linear registration, which is inaccurate.
>
> One thing you can try is to register DTI-b0 and anatomical-T2, which are
> both T2 contrasts. Between these two, you can do non-linear registration.
> This is how we reduce B0 distortion. Then you can register T1-T2 anatomical
> scans by linear registration.
>
> This is the only way I can think of. Namely use the anatomical T2 as a hub
> to do intra-subject multi-contrast registration.
>
> On Tue, Mar 12, 2013 at 3:51 PM, Dorian P. <alb.net at gmail.com> wrote:
>
>> Hi all,
>>
>> What it the best way to register DTI data onto T1? Or, if this is
>> difficult, the way round, register T1 on DTI.
>>
>> I have tried several ways in DTIstudio and Diffeomap without success.
>>
>> Thank you.
>>
>> Dorian
>>
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